@article {162, title = {Chronically implantable LED arrays for behavioral optogenetics in primates}, journal = {Nature Methods}, volume = {18}, year = {2021}, month = {Jan-09-2021}, pages = {1112 - 1116}, abstract = {

Optogenetic methods have been widely used in rodent brains, but remain relatively under-developed for nonhuman primates such as rhesus macaques, an animal model with a large brain expressing sophisticated sensory, motor and cognitive behaviors. To address challenges in behavioral optogenetics in large brains, we developed Opto-Array, a chronically implantable array of light-emitting diodes for high-throughput optogenetic perturbation. We demonstrated that optogenetic silencing in the macaque primary visual cortex with the help of the Opto-Array results in reliable retinotopic visual deficits in a luminance discrimination task. We separately confirmed that Opto-Array illumination results in local neural silencing, and that behavioral effects are not due to tissue heating. These results demonstrate the effectiveness of the Opto-Array for behavioral optogenetic applications in large brains.

}, issn = {1548-7091}, doi = {10.1038/s41592-021-01238-9}, url = {https://www.nature.com/articles/s41592-021-01238-9}, author = {Rajalingham, Rishi and Sorenson, Michael and Azadi, Reza and Bohn, Simon and DiCarlo, James J. and Afraz, Arash} }