@article {162,
	title = {Chronically implantable LED arrays for behavioral optogenetics in primates},
	journal = {Nature Methods},
	volume = {18},
	year = {2021},
	month = {Jan-09-2021},
	pages = {1112 - 1116},
	abstract = {<p>Optogenetic methods have been widely used in rodent brains, but remain relatively under-developed for nonhuman primates such as rhesus macaques, an animal model with a large brain expressing sophisticated sensory, motor and cognitive behaviors. To address challenges in behavioral optogenetics in large brains, we developed Opto-Array, a chronically implantable array of light-emitting diodes for high-throughput optogenetic perturbation. We demonstrated that optogenetic silencing in the macaque primary visual cortex with the help of the Opto-Array results in reliable retinotopic visual deficits in a luminance discrimination task. We separately confirmed that Opto-Array illumination results in local neural silencing, and that behavioral effects are not due to tissue heating. These results demonstrate the effectiveness of the Opto-Array for behavioral optogenetic applications in large brains.</p>
},
	issn = {1548-7091},
	doi = {10.1038/s41592-021-01238-9},
	url = {https://www.nature.com/articles/s41592-021-01238-9},
	author = {Rajalingham, Rishi and Sorenson, Michael and Azadi, Reza and Bohn, Simon and DiCarlo, James J. and Afraz, Arash}
}
@article {149,
	title = {Chronically implantable LED arrays for behavioral optogenetics in primates},
	journal = {bioRxiv},
	year = {2020},
	month = {9/11/2020},
	type = {preprint},
	abstract = {<p>Challenges in behavioral optogenetics in large brains demand development of a chronically implantable platform for light delivery. We have developed Opto-Array, a chronically implantable array of LEDs for high-throughput optogenetic perturbation in non-human primates. We tested the Opto-Array in the primary visual cortex of a macaque monkey, and demonstrated that optogenetic cortical silencing by the Opto-Array results in reliable retinotopic visual deficits on a luminance discrimination task.</p>
},
	doi = {10.1101/2020.09.10.291583},
	url = {https://www.biorxiv.org/content/10.1101/2020.09.10.291583v1.abstract},
	author = {Rajalingham, Rish and Sorenson, Michael and Azadi, Reza and Bohn, Simon and DiCarlo, James J. and Afraz, Arash}
}
