Title | Chronically implantable LED arrays for behavioral optogenetics in primates |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Rajalingham, R, Sorenson, M, Azadi, R, Bohn, S, DiCarlo, JJ, Afraz, A |
Journal | bioRxiv |
Date Published | 9/11/2020 |
Type of Article | preprint |
Abstract | Challenges in behavioral optogenetics in large brains demand development of a chronically implantable platform for light delivery. We have developed Opto-Array, a chronically implantable array of LEDs for high-throughput optogenetic perturbation in non-human primates. We tested the Opto-Array in the primary visual cortex of a macaque monkey, and demonstrated that optogenetic cortical silencing by the Opto-Array results in reliable retinotopic visual deficits on a luminance discrimination task. |
URL | https://www.biorxiv.org/content/10.1101/2020.09.10.291583v1.abstract |
DOI | 10.1101/2020.09.10.291583 |
Refereed Designation | Non-Refereed |