Chronically implantable LED arrays for behavioral optogenetics in primates

TitleChronically implantable LED arrays for behavioral optogenetics in primates
Publication TypeJournal Article
Year of Publication2021
AuthorsRajalingham, R, Sorenson, M, Azadi, R, Bohn, S, DiCarlo, JJ, Afraz, A
JournalNature Methods
Pagination1112 - 1116
Date PublishedJan-09-2021

Optogenetic methods have been widely used in rodent brains, but remain relatively under-developed for nonhuman primates such as rhesus macaques, an animal model with a large brain expressing sophisticated sensory, motor and cognitive behaviors. To address challenges in behavioral optogenetics in large brains, we developed Opto-Array, a chronically implantable array of light-emitting diodes for high-throughput optogenetic perturbation. We demonstrated that optogenetic silencing in the macaque primary visual cortex with the help of the Opto-Array results in reliable retinotopic visual deficits in a luminance discrimination task. We separately confirmed that Opto-Array illumination results in local neural silencing, and that behavioral effects are not due to tissue heating. These results demonstrate the effectiveness of the Opto-Array for behavioral optogenetic applications in large brains.

Short TitleNat Methods